true アポトーシス関与遺伝子、TNF受容体ファミリーに属するI型膜貫通蛋白であるFas遺伝子をノックアウトしたマウス。欠損マウスはリンパ腫と自己免疫疾患を発症する。生後、数ヶ月でCD4ならびにCD8も発現していないポリクローナルな異常T細胞が蓄積し、リンパ節腫や脾腫を引き起こす。Fas欠損マウスでは、lprの異常を最も強く発現するマウスと比較しても、異常T細胞の蓄積、自己抗体の産生とも、さらに加速していることが判明している。 長田　重一 E14.1 [129P2/OlaHsd] <a href='https://brc.riken.jp/mus/pcr01474'>Genotyping protocol -PCR-</a> C（3〜6か月） C (3-6 months) Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj) Apoptosis Research The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature Genetics, 11, 294-300 (1995).RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.<br>The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. E. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Fas genomic DNA 国立大学法人京都大学 B6.129-Fas<tm1Osa>/OsaRbrc B6.129-Fas<tm1Osa>/OsaRbrc Fas is a cell surface receptor belonging to the tumor necrosis factor receptor superfamily which transduces apoptotic signals in many cell types. Fas deficient mutant mice show lymphoma and autoimmune disorders. In a few month after birth, the mice develop lymphadenoma and splenomegaly by an accumulation of abnormal polyclonal T cells with the CD4-CD8- double negative. B6 Fas-KO B6 Fas-KO Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj)Homozygous mutant mice show lymphoma and autoimmune disorders. 50% dead at about 5 months of age. Developed by Drs. Masashi Adachi and Shigekazu Nagata at Osaka University Medical School in 1995. Developed by Drs. Masashi Adachi and Shigekazu Nagata at Osaka University Medical School in 1995. 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Nature Genetics, 11, 294-300 (1995).<br>公表を前提とした学術研究に限る。<br>利用者が本件リソースを使用して得られた研究成果に基づき特許等などの申請及び事業を行う場合は寄託者と別途協議を行う。 Kyoto Univ. Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj) Homozygous mutant mice show lymphoma and autoimmune disorders. 50% dead at about 5 months of age. Immunology and Inflammation Research Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="http://biochemi.ifrec.osaka-u.ac.jp/english/" target="_blank">Lab HP</A> Shigekazu NAGATA RBRC01474